Environmental Science and Studies


Autumn 2013 Environmental Science Seminar Series

Environmental Sciences provides a Seminar Series to the campus and local community on relevant topics.
It is held on Mondays from 12:30pm to 1:25pm in Science 309, unless otherwise noted.

If you have any questions, please contact John Finke at jfinke@uw.edu.

 

UW Tacoma/UW Seattle alumna Amanda C. Watts, '13, published in Cell, August 2013

Spatial and Temporal Mapping of De Novo Mutations in Schizophrenia to a Fetal Prefrontal Cortical Network
Amanda C. Watts, Suleyman Gulsuner, Tom Walsh, Ming K. Lee, Anne M. Thornton, Silvia Casadei, Caitlin Rippey, Hashem Shahin, Consortium on the Genetics of Schizophrenia (COGS), PAARTNERS Study Group, Vishwajit L. Nimgaonkar, Rodney C.P. Go, Robert M. Savage, Neal R. Swerdlow, Raquel E. Gur, David L. Braff, Mary-Claire King, Jon M. McClellan

Abstract

Genes disrupted in schizophrenia may be revealed by de novo mutations in affected persons from otherwise healthy families. Furthermore, during normal brain development, genes are expressed in patterns specific to developmental stage and neuroanatomical structure. We identified de novo mutations in persons with schizophrenia and then mapped the responsible genes onto transcriptome profiles of normal human brain tissues from age 13 weeks gestation to adulthood. In the dorsolateral and ventrolateral prefrontal cortex during fetal development, genes harboring damaging de novo mutations in schizophrenia formed a network significantly enriched for transcriptional coexpression and protein interaction. The 50 genes in the network function in neuronal migration, synaptic transmission, signaling, transcriptional regulation, and transport. These results suggest that disruptions of fetal prefrontal cortical neurogenesis are critical to the pathophysiology of schizophrenia. These results also support the feasibility of integrating genomic and transcriptome analyses to map critical neurodevelopmental processes in time and space in the brain.
 

Green Laboratory Certification Results, July 23, 2013

The results are in: Cline Laboratory has earned a score of 87% and a Gold Level Green Laboratory Certification.
 

Cynthia A. Stanich, PhD published in Biophysical Journal, July 2013Link to Biophysical Journal July 2013

Coarsening Dynamics of Domains in Lipid Membranes
Cynthia A. Stanich, Aurelia R. Honerkamp-Smith, Gregory Garbes Putzel, Christopher S. Warth, Andrea K. Lamprecht, Pritam Mandal, Elizabeth Mann, Thien-An D. Hua, Sarah L. Keller

Abstract

We investigate isothermal diffusion and growth of micron-scale liquid domains within membranes of free-floating giant unilamellar vesicles with diameters between 80 and 250 m. Domains appear after a rapid temperature quench, when the membrane is cooled through a miscibility phase transition such that coexisting liquid phases form. In membranes quenched far from a miscibility critical point, circular domains nucleate and then progress within seconds to late stage coarsening in which domains grow via two mechanisms 1), collision and coalescence of liquid domains, and 2), Ostwald ripening. Both mechanisms are expected to yield the same growth exponent, α = 1/3, where domain radius grows as timeα. We measure α = 0.28 0.05, in excellent agreement. In membranes close to a miscibility critical point, the two liquid phases in the membrane are bicontinuous. A quench near the critical composition results in rapid changes in morphology of elongated domains. In this case, we measure α = 0.50 0.16, consistent with theory and simulation.

 

1st Annual Puyallup River Film Festival: A Competition to Save Our Watershed 1st Annual Puyallup River Film Festival Poster

We need your video-making talents!!! With a generous grant from The Russell Family Foundation, the University of Washington Tacoma will host the first ever film festival focused on our own Puyallup River Watershed. We invite all individuals, schools (middle schools, high schools, and colleges/universities) and non-profit organizations located in or working in the watershed to submit 2- to 3-minute videos related to issues affecting the Puyallup River and its tributaries. Any digital format will be accepted, and the more inventive and original the better!!! All of the information about the competition is available on the poster.

If you have any questions, please contact Jim Gawel at jimgawel@uw.edu.

 

"What is a watershed?"

An educational video created by students from Lincoln High School's Lincoln Center, this is the first video in a series to be created by area schools explaining water management issues in the Puyallup River Watershed.  These videos will be a key part of a new website being developed by Dr. Jim Gawel, Dr. Megan Kogut, staff member Paul Lovelady and student Brenda Smithhisler at UW Tacoma for area students and educators to explore the science and policy of watershed management using the Puyallup River as a model.  This web project, funded by The Russell Family Foundation, builds on the documentary "Water Undone: the Effort to Save the Puyallup River Watershed" released in 2010.

"What is a watershed?" may also be viewed through Vimeo.